Development and Evaluation of a Novel Polymeric Nanoparticle-Based Targeted Drug Delivery System for Cancer Therapy

Abstract

This study presents the design and evaluation of a novel nanotechnology-based targeted drug delivery system for enhancing cancer therapy efficacy. Utilizing a polymeric nanoparticle platform, we engineered a drug delivery system capable of precise targeting and controlled release of anticancer agents. The nanoparticles were functionalized with specific ligands to target overexpressed receptors on tumor cells. In vitro studies demonstrated high binding affinity and selective internalization by cancer cells, while in vivo testing in murine models revealed significant tumor size reduction compared to traditional chemotherapy. Pharmacokinetic analysis confirmed sustained drug release and reduced systemic toxicity. Our findings suggest that this targeted drug delivery system enhances therapeutic outcomes by increasing drug accumulation at the tumor site and minimizing adverse effects on healthy tissues. This study underscores the potential of nanotechnology in developing more effective and safer cancer treatments, paving the way for future clinical applications.